The Science Behind THCv & CBD
In the realm of cannabinoids extracted from the cannabis plant, Tetrahydrocannabivarin (THCv) stands out as a fascinating compound with more research surfacing that supports the evidence of THCv's therapeutic benefits. From appetite suppression, to inflammation and immune system regulation, and neuro-protective qualities. THCv is capturing the attention of scientists and wellness seekers alike. In this article, we will dive into the current science of THCv and its interaction within the brain and body, as well as how CBD can further advance the therapeutic qualities when combined with THCv.
Preface on the Endocannabinoid System (ECS)
The endocannabinoid system is a remarkable regulatory system within the brain and body that helps regulates several physiological processes.. There are two specific receptors that make up the ECS and bind with cannabinoids and phytocannabinoids, and terpenoids. CB1 receptors are found mainly in the central nervous system that consists of the brain and spinal cord. Certain cannabinoids, when bonded to the CB1 receptors, can help regulate neurotransmitter release, influencing mood, cognition, memory, pain perception and motor control. CB2 receptors are found in the peripheral nervous system which connects all communication from your body to your spinal cord and brain. These receptors can be located in your muscles, organs, bone and skin tissues, making the ECS a powerful mediator of immune and inflammatory function in response to illness and injury.
Understanding THCV
By now, you've probably heard of the most common and potent cannabinoid, CBD, within the hemp plant. As more successful studies have aided the growing body of research behind CBD, scientists began to seek a greater understanding of the hemp plant altogether, including minor cannabinoids such as THCv. THCv is a rare, minor cannabinoid found in select strains of the cannabis plant. Interestingly enough, when these certain plants continue to mature, the well-known THC compound converts into the cannabinoid THCv, but at much smaller levels. THCv has been shown to bind with CB1 and CB2 receptors found in the ECS system similar to all cannabinoids, however, with excitingly different outcomes.
THCv in the Brain
When THCv binds to CB1 receptors in the brain it has a very different effect compared to its bigger relative THC. As many who are reading this might concur, Delta 9 THC (the compound responsible for the psychological affects of marijuana) has one distinct quality of causing hunger, otherwise known as "the munchies". This is due to D9 THC activating the CB1 receptor, in turn signaling the release your hunger hormone Ghrelin. THCv, on the other hand, has an antagonistic effect on CB1 receptors. THCv inhibits the CB1 receptor, causing the release of your "I'm full" hormone Leptin. Now, D9 THC has a much greater affinity for these receptors in the brain, so even strains with more percentages of THCv naturally in them will most likely still give you the munchies, but the effect would be reduced.
So what if we take THCv as an extract, without the consumption of D9 THC?
THCv Extract
When THCv is taken without its relative D9 THC, the therapeutic effects on the brain can be magnified. More CB1 receptors are able to be inhibited, which ultimately means greater release of Leptin, your satiation hormone, further suppressing appetite. In recent studies on rats, when given dosages of THCv supplementation, have shown a decrease in appetite, smaller amounts of food eaten when consuming a meal, and noticeable weight loss compared to the placebo group.
Other studies have been done that show other therapeutic benefits of THCv within the brain. Neurotransmitters are chemical messengers in the brain that shape our experience of the world around us through cognition, mood, sleep, motor control, and pain. THCv has been thought to play a role in the enhancement of dopamine release, which is a neurotransmitter known for motivation, happiness, positive reward, and motor control as seen in Parkinson's disease.
THCv in the Body
THCv holds powerful anti-inflammatory properties that can improve how well your immune system functions, especially after an injury or illness. The natural process of inflammation is to trigger signals to your immune system in order to rid the inflamed area of any foreign invaders and debris. If your immune system isn't functioning properly, inflammation can become too much causing ischemia (reduced blood flow) and the natural removal of these invaders can remain harmful to your body and elongate the injury recovery process, or illness effects. THCv has been shown to help regulate the inflammation response and allow the immune system to do its job properly and effectively. This regulatory process has also been seen to be further enhanced when THCv is combined with CBD, as CBD has a high affinity for CB2 receptors in the body.
Conclusion
Overall, many exciting new scientific findings of THCv continue to surface and spotlight the many positive benefits. With almost zero side-effects, except when taken in extremely high amounts, this rare cannabinoid holds the power to transform your life of wellness and weight loss. When combined with CBD, THCv has shown its potential to significantly inhibit CB1 receptors and help suppress appetite, enhance the release of the neurotransmitter dopamine, and regulate the inflammatory and immune responses to injury and illness. Side Note: synthetic versions of THCv does not appear to have the full positive benefits as THCv extracted naturally. Noble Leaf's lab takes extra care when extracting the small but potent THCv cannabinoid.